A combined SAAG ≥ 1.1 g/dL and peritoneal fluid total protein ≥ 2.5 g/dL favors heart failure-induced ascites with 54% sensitivity and 88% specificity, and a brain natriuretic peptide > 364 pg/mL favors cardiac ascites with a sensitivity of 98% and specificity of 99% [12,13]. The gene discussed is NPPB; the disease is heart failure.