Our earlier research explored mRNA profiles of CLL samples at different time points, and we concluded that treatment with 1 μM RG7388 for 6 h was the optimum approach to detect the transcriptional induction of several p53 pathway genes at a time and dose well before the consequent cytotoxic effects and secondary changes in CLL cells become evident [2]. The gene discussed is TP53; the disease is B-cell chronic lymphocytic leukemia.