HMOX1 and frontotemporal dementia: For example, patients with Pick’s disease (frontotemporal dementia) and corticobasal degeneration (CBD), as well as transgenic mouse models of frontotemporal lobar degeneration (FTLD-tau), exhibit elevated levels of various oxidative markers such as malondialdehyde (MDA), 4-hydroxynonenal (4-HNE), SOD1, SOD2, and heme oxygenase-1 (HO-1) [57].