Consequently, elevated levels of NLRP3 and some cytokines were observed in the DRG, sciatic nerves, and/or spinal cords of animals suffering from PTX-, oxaliplatin-, or vincristine-induced peripheral neuropathy [69,73] as well as in the AMG of animals with neuropathic pain caused by chronic constriction of the sciatic nerve [38]. Here, NLRP3 is linked to peripheral neuropathy.