In addition, the exogenous activation of the antioxidant pathway by the administration of several HO-1 inducers inhibits neuropathy and the emotional disorders associated by enhancing the expression of several antioxidant enzymes such as HO-1 and SOD-1 in the DRG and/or AMG of nerve-injured mice [38] and PTX-injected animals [22], but the action of CoPP plus HRW on antioxidant protein levels has not analyzed. The gene discussed is HMOX1; the disease is neuropathy.