However, similar to the current study, we have recently shown that a prophylactic apocynin treatment was able to prevent social recognition memory impairments but not neophobia, alongside a complete prevention of microglial activation in the suprachiasmatic nucleus of the hypothalamus [3], thus suggesting that whilst antioxidant treatment may improve recognition memory, inhibition of NOX2 activity is crucial to improving both microglial profiles and anxiety-like behaviors in CS-exposed mice but not recognition memory. This evidence concerns the gene CYBB and Anxiety.