This study not only reveals the new effects of lipotoxicity on vascular aging from the perspectives of ROS/ERK and ferroptosis pathways at the cellular and molecular levels but also elucidates new mechanisms of vascular protection by CAN, providing new references for the development of anti-vascular-aging-related drugs in the future. The gene discussed is MAPK1; the disease is Crouzon syndrome-acanthosis nigricans syndrome.