GLO1 and neoplasm: In addition, challenging the traditional view of curcumin as an antioxidant, studies have also reported that it can target and bind to multiple enzymes involved in the ROS metabolic pathway, including carbonyl reductase 1 (CBR1), glutathione-S-transferase phi 1 (GSTP1), aldo-keto reductase family 1 member 1 (AKR1C1), glyoxalase I (GLO1), and so on, resulting in increased ROS levels in leukemia cells and suppressed tumor growth [105].