The overexpression of G6PD in 3T3-L1 preadipocytes stimulated the expression of adipocyte markers, increased triglyceride accumulation and the release of free fatty acids, increased the expression of proinflammatory cytokines such as TNF-α and resistin, decreased the expression of cytoprotective adiponectin, and stimulated insulin resistance [50]. The gene discussed is G6PD; the disease is Insulin resistance.