H6PD and Insulin resistance: Increasing WAT ER [NADPH]/[NADP+] in mice via hexose-6-phosphate dehydrogenase (H6PD) overexpression increased WAT NADPH-dependent 11β-hydroxysteroid dehydrogenase type 1 activity and cortiocosterone production, leading to slight weight gain, glucose intolerance, and insulin resistance [47].