CXCL8 and colorectal carcinoma: Similarly, the combination of resveratrol and oxaliplatin showed synergistic effects in increasing different forms of cell deaths (apoptosis and primary/secondary necrosis in Caco-2 CRC cells), while the conditioned medium of co-treated cells significantly increased the release of pro-inflammatory cytokines TNF-α and IL-8 from human macrophages [120].