This study showed that EGCG treatment resulted in the suppression of Notch1, Bmi1, Suz12, and Ezh2 and upregulated self-renewal-suppressive miRNAs, (miR-34a, miR-145, and miR-200c), which are the key components often dysregulated in 5FU-resistant CRC cells [156]. Here, NOTCH1 is linked to colorectal carcinoma.