HSPA5 and colorectal carcinoma: Subsequently, this led to the activation of the apoptotic cascade (caspase-3 and PARP activation, Bcl-2 reduction, and Bad overexpression), suggesting that EGCG could enhance 5-FU sensitivity via the GRP78/NF-κB/miR-155-5p/MDR1 pathway in CRC cells [157].