PIK3CA and colorectal carcinoma: Research has shown that the combination of resveratrol and curcumin can activate pro-apoptotic genes, including PMAIP1, BID, ZMAT3, CASP3, CASP7, and FAS, in CRC cells, depending on mutational profiles (KRAS, PIK3CA, PTEN, BRAF, and TP53) [146].