However, peroxidasin/VPO1 is upregulated in vivo in inflamed or diseased cardiovascular tissue including human and mouse abdominal aortic aneurysms [220], atherosclerotic lesions in apoE−/− mice [221] and in response to pathogenic stimuli, including angiotensin II [222,223]. The gene discussed is PXDN; the disease is abdominal aortic aneurysm.