Although NFE2L2 mutations are relatively rare, it has been reported that DLG motif mutations in NRF2 in hepatocellular carcinoma (HCC) and NRF2-mutant HNSCC cell lines upregulated NRF2 transcriptional activity and might promote chemoradiation resistance [67,68]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.