Moreover, genetic ablation of the inhibitor of apoptosis stimulating protein of p53 (iASPP)/NRF2/macrophage-colony stimulating factor (M-CSF) axis suppressed the growth of doxorubicin-resistant colon cancer xenografts, indicating that the interaction between iASPP and KEAP1 was responsible for mediating chemotherapy resistance [96]. Here, PPP1R13L is linked to malignant colon neoplasm.