Early studies on miRNAs revealed that the abundance of miR-144 was lower in 5-fluorouracil-resistant HCC and that the abundance of miR-144-3p was lower in cisplatin-resistant lung cancer cells [79,80], while transfection with miR-144 mimics or the re-expression of NRF2 reversed this resistance phenotype. Here, NFE2L2 is linked to hepatocellular carcinoma.