PRDX3, which is specific to mitochondria, is stabilized by prohibitin (PHB) in glioma CSCs to suppress the production of mitochondrial ROS, thereby conferring resistance to radiotherapy in glioma [199], and the regulation of stemness by PRDX1/2/3 has also been found in colon cancer resistant to 5-fluorouracil [200,201]. The gene discussed is PHB1; the disease is central nervous system cancer.