Subsequently, p62 sequesters KEAP1 in autophagosomes, thereby reducing NRF2 ubiquitination, increasing NRF2 stability, and activating antioxidant/detoxifying genes such as NAD(P)H quinone dehydrogenase 1 (NQO1) and heme oxygenase 1 (HMOX1) to protect HCC cells from ferroptosis induced by erastin and sorafenib [92,93]. Here, NFE2L2 is linked to hepatocellular carcinoma.