FH and renal cell adenocarcinoma: Moreover, germline mutations in the fumarate hydratase (FH) gene that predispose to hereditary leiomyomatosis (a benign tumor of smooth muscle origin) and renal cell cancer (HLRCC) cause a buildup of fumarate that leads to the formation of succinic GSH, a covalent conjugate between fumarate and GSH [38].