WAT is predominantly found in subcutaneous deposits around the abdomen and visceral areas, producing adipokines and factors that regulate energy balance and obesity, including leptin; adiponectin; angiotensinogen; and cytokines such as interleukin-1beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), interleukin-10 (IL-10), tumor necrosis factor-alpha (TNF-α), chemokines, and profibrotic substances like transforming growth factor-beta (TGF-β) [17,18]. The gene discussed is LEP; the disease is obesity due to melanocortin 4 receptor deficiency.