In addition, Nfe2l1-specific knockout in mouse liver, pancreatic β cells, brain, white adipose tissue, and osteoblasts and osteoclasts cause non-alcoholic steatohepatitis (NASH) [10,11], hyperinsulinemia [12], neurodegenerative disease [13,14], inflammation in white adipose tissue [15], and skeletal retardation [16,17], respectively. The gene discussed is NFE2L1; the disease is metabolic dysfunction-associated steatohepatitis.