Given the scarce data on the association between BMI, abdominal obesity, and target organ damage (such as blood vessels, heart, and liver), this study aimed at elucidating the association between the obesity with the risk of early subclinical target organ damage and specific biochemical parameters (ox-LDL-Chol, NO metabolites, iNOS, and PAI-1). Here, NOS2 is linked to obesity due to melanocortin 4 receptor deficiency.