Recent studies on immune cell infiltration in canine gliomas have demonstrated increased numbers of CD3 + and FOXP3 + TILs in high-grade tumors, particularly in astrocytomas, and M2 polarization of macrophagic infiltrates in high-grade gliomas, mirroring similar TIME to that described for human gliomas [34,56]. The gene discussed is FOXP3; the disease is central nervous system cancer.