Several studies confirmed that the loss of PTEN expression in human gliomas induce changes in cytokine secretion pattern, promoting an immune-suppressive microenvironment characterized by reduction in tumor infiltrating lymphocytes (TILs) and increased immune cell populations that can promote tumor progression, such as regulatory T cells (Tregs) and M2 macrophages [51,52,53,54,55]. Here, PTEN is linked to central nervous system cancer.