TP53 and central nervous system cancer: Although our understanding of the molecular landscape of canine gliomas has greatly expanded in the last few years, with several studies demonstrating similarities and differences to human glioma, further investigations regarding abnormalities in major molecular pathways such as TP53, cell cycle regulators, and core members of major signaling pathways involved in both human and canine gliomagenesis and progression are required [9,10,11].