When considering the threshold for a one-tailed p-value of <0.05, provided after adjusting for multiple testing [43], only six pathways were found to be significantly impacted, including branched-chain amino acid catabolism, glucose-6-phosphate dehydrogenase deficiency, ribose-5-phosphate isomerase deficiency, transaldolase deficiency, the valproic acid metabolism pathway, and the valproic acid pathway. Here, RPIA is linked to transaldolase deficiency.