Notably, among the 15 variables associated with an elevated risk of young-onset dementia in this study in the fully adjusted models (lower formal education, social isolation, lack of use of alcohol, alcohol use disorder, diabetes, hearing impairment, heart disease, high C-reactive protein, lower hand-grip strength, orthostatic hypotension, stroke, two apolipoprotein ε4 alleles, and vitamin D deficiency), only the hazard ratio for orthostatic hypotension was higher than the hazard ratio for depression [15]. This evidence concerns the gene CRP and orthostatic hypotension.