TNF and congenital rubella syndrome: Both in vitro and in vivo, cytokine release syndrome (CRS)-related cytokines such as TNF-α, IL-6, and CCL2 are secreted by CAR macrophages (CAR-M) at levels showing a 1.5- to 10-fold increase, compared to the 30- to 8000-fold increase observed after CAR-T cell injection.