RNA sequencing of the tumor from a humanized mouse model 5 days after CAR-M injection confirmed two distinct clusters of untransduced (UT)- and CAR-Ms, with the CAR-M cluster showing an increased expression of pro-inflammatory genes (TNF, MHC II), indicating the remodeling effect of CAR-M cells on the TME [67]. The gene discussed is TNF; the disease is neoplasm.