The co-cultivation of CAR-T cells with CAR-DCs to target Kasumi-1 tumor cells demonstrated increased cytotoxicity (78.4% CAR-DC+CAR-T vs. 39.9% CAR-T vs. 17.6% eGFP T cells) and production of IFN-γ, TNF-α and IL-12 compared to CAR-T alone or the eGFP-control. The gene discussed is TNF; the disease is neoplasm.