CASP3 and melanoma: On melanotic melanoma (A375) and amelanotic melanoma (C32) cell lines, human keratinocytes (HaCaT), and human fibroblasts (HGF), Szlasa et al. [130] found that concentrations of curcumin ranging from 5 μM to 50 μM and a wavelength of 410 nm induced increased cell death, increased expression of caspase-3, and DNA cleavage.