Later, SerpinB3 was found to be highly expressed in various types of squamous cancers other than that of the uterine cervix, including head and neck, breast, esophageal, and primary liver cancers (HCC, cholangiocarcinoma [CCA] and hepatoblastoma [HB]), being associated with poor prognosis and a higher risk of recurrence [70,71,72,73,74,75]. Here, SERPINB3 is linked to hepatocellular carcinoma.