Regarding its role in the immune response, in cervical tumors, SerpinB3 was found to protect neoplastic cervical cells against radiotherapy (RT)-induced damage by preventing lysoptosis [99], and patients with persistently high levels of SerpinB3 before and during RT had a higher risk of recurrence and death [73]. The gene discussed is SERPINB3; the disease is uterine cervix neoplasm.