The first study that connected SerpinB3 and the progression of a fibrogenic chronic disease was made by Calabrese et al. [20] as they investigated the role of SerpinB3 in metaplastic epithelial cells in idiopathic pulmonary fibrosis (IPF), a progressive chronic disease with a poor prognosis. The gene discussed is SERPINB3; the disease is idiopathic pulmonary fibrosis.