Immunohistochemically, epithelioid hemangiomas are characterized by the strong expression of vascular markers (CD31 and ERG); the variable expression of FOS and/or FOSB; and negativity for pan-keratin AE1/AE3 (typical of pseudomyogenic hemangioendothelioma), CAMTA1 and TFE3 (peculiar of epithelioid hemangioendothelioma), and MYC (found in some cases of epithelioid angiosarcoma) [9,10]. This evidence concerns the gene PECAM1 and epithelioid hemangioendothelioma.