After BVZ treatment, some glioblastomas can stimulate the growth of tumor vessels by expressing various angiogenic factors or elevated expression levels, such as EGFR vIII-positive GBM with BVZ treatment [21] and enhanced bFGF (Fibroblast Growth Factor 2) expression [22], showing worse outcomes of BVZ treatment. The gene discussed is EGFR; the disease is glioblastoma.