E2F8 and glioblastoma: Furthermore, the regulatory gene network of E2F8 was explored by integrating DE gene expression in the BVZ responsive subtype of GBM before and after treatment into the current BioGrid network, as shown in Figure 5D. The protein–protein interaction (PPI) network data were organized and visualized using Cytoscape, and 25 nodes and 78 edges were found in the PPI network (all nodes are shown in Supplementary Table S2).