The expression levels of STUB1 (STIP1 Homology And U-Box Containing Protein 1, E3 Ubiquitin) and YWHAQ (Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase) were significantly increased after BVZ treatment in BVZ-responsive subtype of GBM, indicating their involvement in the E2F8 network and potential regulation by E2F8. The gene discussed is STUB1; the disease is glioblastoma.