Blocking of B7H4 using a monoclonal antibody in a mouse model of muscle-invasive bladder cancer (N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN)) leads to reduced tumour size, an increase in number of CD8 T cell infiltrating the tumour, and a decrease in Tregs infiltration. The gene discussed is VTCN1; the disease is neoplasm.