Nevertheless, we cannot rule out that E-Syt1 and E-Syt2 participate in cell migration and viability by mechanisms different from Ca2+ signaling, as membrane contact sites have been reported to be essential for cancer progression [42], but attenuation of SOCE in breast cancer cells has been reported to have significant effects on cell viability and cell cycle progression [27,33,43]. Here, ESYT1 is linked to breast carcinoma.