In contrast, while PRRT also showed an increase in 53BP1 foci numbers at day 0 (assessed directly post-PRRT), meningioma spheroids still showed significantly elevated 53BP1 levels at day 2 post-PRRT, correlating with the extended irradiation time of PRRT as compared to EBRT (Figure 4 and Figure S2). The gene discussed is TP53BP1; the disease is meningioma.