In addition, ENO2 has been found to interact with PKM2, preventing PKM2 ubiquitin-mediated proteasomal degradation and regulating PKM2-driven CCND1-mediated cell cycle progression, proliferation, and glycolysis in head and neck squamous cell carcinoma (HNSCC) [11]. The gene discussed is CCND1; the disease is head and neck squamous cell carcinoma.