In this study, we found that a high degree of M2-TAM infiltration and the activation of STAT3/NF-κB signaling in TME of cervical cancer was associated with the upregulation of expression of protein factors related to immunosuppression, EMT, invasion, resistance to apoptosis, angiogenesis, and proliferation, which resonated in adverse clinical and pathological prognostic parameters. Here, STAT3 is linked to cervical cancer.