M2-TAM and STAT3/NF-κB pathways upregulated the expression of immunosuppressive components, leading to a stimulatory loop in EMT, invasion, angiogenesis, apoptosis resistance, and proliferation, which negatively reverberated on the clinic parameters, including TNM stage, disease recurrence, and death in 691 patients with cervical cancer. This evidence concerns the gene STAT3 and cervical cancer.