FGFR1 and central nervous system cancer: A recent comprehensive genomic study of H3F3A-mutant high-grade gliomas revealed that FGFR1 hotspot point mutations (N546K and K656E) were exclusively identified in H3 K27M-mutant DMGs (64/304, 21%); these tend to occur in older patients (median age: 32.5 years) and mainly arise in the diencephalon [54, 58].