In our experiments, BA and DDP increased the ratio of F4/80+ and CD11c+ and induced the accumulation of iNOS and TNF-α in cells and inhibited the activities of VEGF-A and TGF-β, indicating that BA and DDP promote M1 macrophage polarization in NSCLC. This evidence concerns the gene TGFB1 and non-small cell lung carcinoma.