Exposure to Eo33-EV, but not to Eo5-EV, up-regulated cyclin-dependent kinase inhibitor (CDKI) protein-related genes in tumor cells, specifically Cdkn1b and Cdkn2b in B16 cells (Fig. 3D) and Cdkn2b and Cdkn1a in TC1 cells (Fig. 3E). Here, CDKN2B is linked to neoplasm.