Similarly, mouse tumor cells co-cultured with Eo33 or exposed to Eo33-EV expressed significantly higher levels of Cdh1 gene and surface E-Cadherin and with concomitant down-modulation of Cdh2. Loss of E-cadherin expression and acquisition of N-cadherin are critical steps in cancer dissemination [44]. This evidence concerns the gene CDH2 and cancer.