We tested the distribution of Nec-1-Exos in various organs after tail vein injection, and the results showed that relative to the exosomes in those of HF rats injected with blank-Exos, the exosomes increased in the heart, lungs, kidneys, and colon but decreased in the liver and spleen of HF rats injected with Nec-1-Exos (Fig. S1). The gene discussed is PCSK1; the disease is hydrops fetalis.