WNK2 and posterior cortical atrophy: Through the enrichment of GO and KEGG pathways, it is predicted that the potential pathways and targets of LWDHD in the intervention of PCa include phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT), mitogen activated protein kinase (MAPK), TP53 pathway, MYC, TNF signaling pathway, etc. The PI3K-AKT-mTOR pathway interacts with AR, MAPK, and WNT signaling cascades to promote the growth and drug resistance of PA [27].