MAPKs, a family of serine-threonine kinases, activate AR signaling by enhancing the expression of GAT2 mRNA and inhibiting the ubiquitination and degradation of GATA2 protein, while the synergistic activation of GAT2/AR and AKT pathways is essential for promoting the growth of PCa cells [28–30]. Here, GATA2 is linked to posterior cortical atrophy.