ESR1 and invasive breast carcinoma: Of these, an increased risk of BrCa was found for higher BMI in postmenopausal women (BrCa, ER + and ER + /PR + BrCa) [7], body weight in postmenopausal women (ER + /PR + BrCa) [137], height [300], weight gain in postmenopausal women [7, 179], estradiol levels [182], Wolfe grade (P1, P2, Dy versus N1) [49], breast density (≥ 75% vs < 25%; ER + BrCa) [247], estrogen-progestin therapy [85] and digoxin use (BrCa, ER + BrCa) [65], ever active smoking [8], higher educational level [116], and diabetes mellitus [242].