Moreover, in contrast to the Asthma + oe-NC + IDF-11,774 group, the Asthma + oe-MDM2 + IDF-11,774 group exhibited a significant increase in inflammatory cell infiltration in alveolar septa and spaces, substantial deposition of collagen and elastic fibers in the airway walls, and marked increases in the areas of airway smooth muscle, epithelial thickness, and bronchoconstriction index (Fig. 6E-K). This evidence concerns the gene MDM2 and asthma.