More recently, Petrone and collaborators have used a combination of humoral markers; AgB-specific IL-1ra, IL-6, IL-8, FGF, G-CFS, IFN-γ, MIP-1α, IP-10 and MCP-1; to monitor specific activity of the immune system and suggesting a potential role in determining cyst(s) viability linked to the reduction of the markers over time [21]. This evidence concerns the gene CCL3 and cyst.