The risk alleles which contribute to the clustering include, rs10876864 (TF binding site variant of IKZF4, SUOX and involved in disease like asthma, allergic diseases, squamous cell carcinoma, vitiligo), rs2687812 (intron variant of TG and involved in vitiligo) and rs34346645 (intron variant of FOXP1 involved in vitiligo), rs9611565 (intron variant of TEF involved in vitiligo) which are found to be highly enriched only in AFR and EAS populations respectively. The gene discussed is IKZF4; the disease is allergic disease.