For instance, rs4766578 belonging to gene ATXN2 (contributing towards the pathogenesis of vitiligo, cardiovascular diseases and involved in haematological parameters governing platelet counts and volume) and rs10774624 (involved in rheumatoid arthritis, preeclampsia, heart diseases) was found to be highly enriched in EUR and AMR1 populations and depleted in AFR and EAS thereby indicating the frequent occurrence of these alleles in the populations belonging to European ancestry [6, 24, 45, 46, 74, 75]. The gene discussed is ATXN2; the disease is rheumatoid arthritis.