Total RNA obtained from HPV negative histologically normal controls and HPV16 positive cervical cancers having either low or high HOTAIR expression levels were compared to identify transcriptome level differences [13, 14].In this study, six DEGs, TOP2A, AURKA, CCNA2, KRT1, IVL and IGFBP5, were screened out through the GSE63514 and GSE67522 datasets. The gene discussed is KRT1; the disease is cervical cancer.