Therefore, immunohistochemical analysis of TOP2A, AURKA, CCNA2, KRT1, IVL and IGFBP5 were performed through The Human Protein Atlas database and it revealed that these protein were positive in cervical cancer tissues except IGFBP5. The antibody HPA006458 was used to detect TOP2A at medium intensity with the proportion of stained cells < 25% in normal cervix tissues, while in cervical cancer tissues, it showed high intensity staining with the proportion of stained cells ranging from 25 to 75%. This evidence concerns the gene IGFBP5 and cervical cancer.