TOP2A and cervical cancer: As shown in Fig. 9, compared with normal tissues, TOP2A, AURKA, CCNA2 and IVL in cervical cancer tissues were significantly up-regulated, while IGFBP5 was significantly down-regulated, and there was no statistical difference in the expression of KRT1 in cervical cancer tissues and normal tissues, which were consistent with the analysis results of TCGA database.