As shown in Fig. 9, compared with normal tissues, TOP2A, AURKA, CCNA2 and IVL in cervical cancer tissues were significantly up-regulated, while IGFBP5 was significantly down-regulated, and there was no statistical difference in the expression of KRT1 in cervical cancer tissues and normal tissues, which were consistent with the analysis results of TCGA database. The gene discussed is IGFBP5; the disease is cervical carcinoma.