CRX and Leber congenital amaurosis: The discovery of de novo mutations in CRX, OTX2, and IMPDH1, which are associated with LCA, has sparked a discussion on the potential presence of dominant inheritance patterns in certain cases of LCA (Rivolta et al. 2001; Bowne et al. 2006; Zou et al. 2013; Roger et al. 2014).