In addition, survival analysis revealed that only a few VGSC mutations had a significant effect on overall survival, such as SCN3B in breast cancer (BRCA); however, this result should be interpreted with caution due to the low case number of the BRCA cohort, with only three cases of SCN3B mutation in BRCA (S- Fig. 2C). The gene discussed is SCN3B; the disease is breast cancer.