YTHDF1 and Miyoshi myopathy: YTHDF1 depletion notably diminished the levels of glycolysis-enhancing genes, glucose uptake, and lactate production (Fig. 6A-C), hindered MM cell viability and proliferation percentage (Fig. 6D/E), resulted in significant aggregation of G0/G1 phase cells, significant declines in S and G2/M phase cells, and visibly increased apoptosis (Fig. 6F/G) (all P < 0.01).