GSEA established the KEGG analysis of TOMM40. As illustrated in Fig. 5A. According to the findings, the TOMM40-related genes played a significant role in immune response and cancer signaling pathways, including Th17 cell differentiation, Natural killer cell mediated cytotoxicity, B cell receptor signaling pathway, Wnt signaling pathway, and Central carbon metabolism in cancer (P < 0.01). This evidence concerns the gene TOMM40 and cancer.