In addition, a monocentric, randomized controlled trial that included patients with sepsis or acute respiratory distress syndrome showed that combination of five amino acids (THR, PRO, SER, cysteine and LEU) with enteral feeding increased plasma CIT levels, reduced ALT and alkaline phosphatase levels and improved muscle and gut functionality compared with placebo group (Heming et al. 2022). The gene discussed is GPT; the disease is acute respiratory distress syndrome.