Tnip1D485N mice exhibit dysregulated NF-κB, c-Jun N-terminal kinase and p38α mitogen-activated protein kinase proinflammatory signaling7 with autoimmunity ameliorated by Toll-like receptor 7 (TLR7) and MyD88 deficiency or interleukin-1 receptor-associated kinase 1 (IRAK1) and interleukin-1 receptor-associated kinase 4 (IRAK4)-inactivating mutations7,9,10. The gene discussed is IRAK4; the disease is Autoimmunity.