Although vikala mice share phenotypic features with previously reported TNIP1 loss-of-function (LOF) mice, our study revealed that TNIP1Q333P does not cause autoimmunity by enhancing NF-κB activation, but rather enhances IFN1 signaling and impairs Myddosome11 and mitochondrial recruitment to autophagosomes. The gene discussed is TNIP1; the disease is Autoimmunity.