DHFR and leukemia: Therefore, DHFR and its gene amplification are potential targets for anti-leukemia drugs (Eyilcim et al. 2023; Gervasini et al. 2017; Kim et al. 2021; Kodidela et al. 2015; Milosevic et al. 2019; Oiwa et al. 2021; Wińska et al. 2019).