IREB2 and leukemia: Multidrug-resistant (MDR) K562/adriamycin (ADM) leukemia cells have higher GSH levels and iron-regulatory protein 2 (IRP2), transferrin receptor, ferritin heavy chain 1 (FTH1), and GPX4 expression, which may enhance their antioxidantcapacity and protect K562/ADM cells from ferroptosis (Zhang et al. 2022).