TXNRD1 and chronic myelogenous leukemia, BCR-ABL1 positive: These results have been confirmed by studies showing that cysteine depletion induces cell death in chronic myeloid leukemia (CML) and AML through ferroptosis, involving thioredoxin reductase 1 (TXNRD1) and glutathione peroxidase 4 (GPX4) (Cunningham et al. 2024; Liu et al. 2021).