KMT2A and leukemia: Two distinct isoforms of MAT are encoded by the genes methionine adenosyltransferase 1 A (MAT1A) and methionine adenosyltransferase 2 A (MAT2A), with MAT1A expressed in the liver and MAT2A expressed in extrahepatic tissues (Nordgren et al. 2011) The use of the MAT2A inhibitor PF-9366 and the knockdown of MAT2A via small interfering RNA (siRNA) in a human CRISPR/Cas9-MLL-rearranged (CRISPR/Cas9-MLLr) leukemia model resulted in alterations to several cellular processes, including proliferation, viability, differentiation, apoptosis, the cell cycle, and histone methylation (Secker et al. 2020).