In a Atp7b−/− mouse model [12–15], miR-122-5p and miR-192-5p in serum mirrored the pattern observed in patients, while liver levels of both miRNAs decreased, especially at 40 weeks, coinciding with the progression from chronic hepatitis (30 weeks) to cirrhosis (36–44 weeks) [14]. This evidence concerns the gene ATP7B and Cirrhosis.