In a Atp7b−/− mouse model [12–15], miR-122-5p and miR-192-5p in serum mirrored the pattern observed in patients, while liver levels of both miRNAs decreased, especially at 40 weeks, coinciding with the progression from chronic hepatitis (30 weeks) to cirrhosis (36–44 weeks) [14]. The gene discussed is ATP7B; the disease is chronic hepatitis.