INS and hydrops fetalis: As expected, obese mice showed impaired glucose tolerance (Figure S1B, P < 0.001, One-way ANOVA followed by Tukey posttest) and displayed poor ability to lower circulating glucose levels upon insulin injection (Figure S1C; P < 0.001, One-way ANOVA followed by Tukey posttest), evidencing abnormal high glucose levels and systemic insulin resistance associated to HF-diet feeding.