In post-COVID-19 brains, we did not observe a significant increase of alpha-synuclein aggregates, a hallmark of several neuropathological conditions that show microglia nodules such as Parkinson’s disease (PD), dementia with Lewy Bodies (DLB), multiple system atrophy (MSA), and others [11] (Fig. 2d). This evidence concerns the gene SNCA and multiple system atrophy.