FOXM1 and cancer: Indeed, the high expression of FOXM1 in numerous cancer cell lines and a variety of tumors is always associated with tumor initiation [17], development [18], invasion [19, 20], metastases [5, 7, 21–23] and poor prognosis [24–26] by directly potentiating the expression of tumor-related genes, such as ERα [27], TOPO-2α [28], c-Myc [17], DLX1 [19] and PDGF-A [29].