To further confirm that Fn14 receptor activation is linked to the glucose metabolism of cachexia-inducing tumours, we investigated [18F]FDG imaging in C26 wildtype tumours (C26 Fn14 WT) expressing Fn14 versus C26 Fn14 knock-out tumours (C26 Fn14 KO) (Fig. 3a). This evidence concerns the gene TNFRSF12A and neoplasm.