TNFRSF12A and neoplasm: In non-cachectic mice bearing C26 Fn14 KO tumours, [18F]FDG tumour uptake was significantly lower (P < 0.01) (SUVaverage, 0.70 ± 0.09; % maximum body weight, 96.66 ± 0.85; n = 5) than in cachectic mice bearing C26 Fn14 WT tumours (SUVaverage, 1.73 ± 0.72; % maximum body weight, 87.33 ± 6.96; n = 9) (Fig. 3e-f).