TNFRSF12A and neoplasm: There was an increase in lactate production (nmol/mg tumour ± SEM) in cachexia-inducing MEF Fn14 tumours (340.0 ± 0.0, n = 2) compared to non-cachexia-inducing MEF tumours (205.4 ± 4.6, n = 2; P < 0.01) (Fig. 4a).